科研专家：周洁

于2020年毕业于福州大学，导师：杨黄浩。

于2021年入职福建医科大学药学，讲师。

研究工作主要聚焦于生物大分子药物递送载体的研究，针对核酸药物、抗体药物等存在的稳定性差、生物利用度低等问题，开发了特色的硫醇载体，与核酸、抗体等复合形成纳米药物，在吸入给药治疗肺部疾病中取得了良好的治疗效果。相关研究成果发表在Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、ACS Appl. Bio Mater.、Chem. Comm.等国际知名期刊上。

(1) J. Zhou, L. Sun, L. Wang, Y. Liu, J. Li, J. Li, J. Li, H. H. Yang, Self-assembled and size-controllable oligonucleotide nanospheres for effective antisense gene delivery through an endocytosis-independent pathway, Angew. Chem. Int. Ed. 2019, 58, 5236–5240.

(2) K. Chen, J. Zhou, Z. Shao, J. Liu, J. Song, R. Wang, J. Li, W. Tan, Aptamer as a Versatile Molecular Tool for Antibody Production Monitoring and Quality Control, J. Am. Chem. Soc. 2020, 142(28), 12079−12086. 

(3) J. Zhou, Z. Shao, J. Liu, Q. Duan, X. Wang, J. Li, H. H. Yang, From endocytosis to non-endocytosis: the emerging era of gene delivery, ACS Appl. Bio Mater. 2020, 3(5), 2686–2701. 

(4) J. Li#, J. Zhou#, T. Liu, S. Chen, J. Li, H. H. Yang, Circular DNA: a stable probe for highly efficient mRNA imaging and gene therapy in living cells, Chem. Commun. 2018, 54, 896–899.