科研专家：韩守法

      博士后（The Scripps Research Institute） 

 研究兴趣：

      基于有机小分子的疾病关联细胞器变化分析与功能调控，糖探针调控炎症反应与肿瘤免疫识别（有机、化学生物学专业招生） 

近期主要代表论著：

      1.Responsive hetero-organelle partition conferred fluorogenic sensing of mitochondrial depolarization; Zhongwei Xue, Hu Zhao, Jian Liu, Jiahuai Han, Shoufa Han*, Chem. Sci. 2017, 8, 1915-1921

      2.Imaging lysosomal pH alteration in stressed cells with a sensitive ratiometric fluorescence sensor, Zhongwei Xue, Hu Zhao, Jian Liu, aJiahuai Han, Shoufa Han*, ACS Sensors. 2017, 2, 436-442

      3.Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface, Bijuan Lin, Xuanjun Wu, Hu Zhao, Yunpeng Tian, Jian Liu, Jiahuai Han, and Shoufa Han*, Chem. Sci. 2016, 7, 3737-3741

      4.A carbohydrate-grafted nanovesicle for fluorescence and acoustic imaging of tumors, Xuanjun Wu, Bijuan Lin, Mingzhu Yu, Jiahuai Han, Shoufa Han*, Chem. Sci. 2015, 6, 2002-2009

      5.A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation; Xuanjun Wu, Mingzhu Yu, Bijuan Lin, Hongjie Xing, Jiahuai Han, and Shoufa Han*, Chem. Sci. 2015, 6, 798-803

      6.Optical Tracking of Phagocytosis with an Activatable Profluorophore Metabolically Incorporated into Bacterial Peptidoglycan; Yunpeng Tian, Mingzu Yu, Zhu Li, Jiahuai Han, Liu Yang*, Shoufa Han*, Anal. Chem., 2015, 87, 8381-8386

      7.Lysosomal pH Decrease in Inflammatory Cells Used To Enable Activatable Imaging of Inflammation with a Sialic Acid Conjugated Profluorophore; Mingzhu Yu, Xuanjun Wu, Bijuan Lin, Jiahuai Han, Liu Yang, and Shoufa Han*, Anal. Chem., 2015, 87, 6688-6695

      8.A self-referenced nanodosimeter for reaction based ratiometric detection of hypochlorous acid in living cells，Xuanjun Wu, Zhu Li, Yuhui Yang, Liu Yang, Jiahuai Han and Shoufa Han* Chem. Sci., 2013, 460-467

      9.Rhodamine-deoxylactam functionalized poly[styrene-alter-(maleic acid)] as lysosome activatable probes for intraoperative detection of tumors，Zhu Li, Yunlong Song, Yuhui Yang, Liu Yang, Xiaohong Huang, Jiahuai Han and Shoufa Han*, Chem. Sci., 2012, 2, 2941-2948